Balacaturbhadrika churna is a renowned Ayurvedic formulation used in pediatric practice. The purpose of present study is to evaluate the role of Balacaturbhadrika churna against experimental induced immunological pleurisy and inflammation in rats to provide scientific evidence for their therapeutic efficacy and substantiate its traditional claim. Balacaturbhadrika churna was prepared as per Ayurvedic Formulary of India and was tested against carrageenan induced paw oedema and triple antigen induced immunological pleurisy (air way inflammation) in albino rats. Balacaturbhadrika churna at dose level of 100 mg/kg and 200 mg/kg did not produce significant suppression of carrageenan hind paw oedema in rats. The drug did not affect the volume of pleural fluid indicating it has no effect on the fluid exudation. This is conformity with the observation that it does not have anti-inflammatory activity. However significant decrease in the cell content of the pleural fluid was observed at both dose levels which indicate that it may inhibit the migration of inflammatory cells to the site of inflammation. From the present study, it can be inferred that effects of Balacaturbhadrika churna on air way inflammation mediated through, by interfering with the activation of T-lymphocytes or inhibition of cytokine secretion from lymphocytes.
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